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How can NMN supplementation increase NAD+levels? This is because NMN is a precursor of NAD+, which is a substance that can be converted into NAD+. In the human body, NMN can be converted into NAD+through two pathways: one is directly synthesized through NMNAT enzyme; Another method is to convert NRK enzyme into NR (nicotinamide riboside), which is then synthesized by NRK enzyme and NRAMPT enzyme. Both of these pathways exist in different tissues and cells of the human body, so supplementing NMN can effectively improve the NAD+levels in various parts of the body.

The mechanism of action of NMN supplementation is mainly achieved by increasing the level of NAD+in the human body. NAD+is a coenzyme, a molecule that helps enzymes catalyze reactions. In the human body, NAD+is involved in the reactions of hundreds of enzymes, involving important functions such as cellular energy metabolism, DNA repair, gene expression, and antioxidant stress. Among them, a special type of enzyme is called sirtuins protein, which can regulate cell lifespan, differentiation, and anti-aging. Sirtuins proteins require NAD+as a coenzyme to function. Therefore, increasing NAD+levels can activate sirtuins proteins, thereby delaying the aging process.

The history and development of NMN supplementation can be traced back to the end of the last century, when scientists discovered the important role of NAD+and sirtuins proteins in the aging process. They began to search for a substance that could increase NAD+levels, thereby delaying the aging process. Initially, they discovered two substances, NA (nicotinic acid) and NAM (nicotinamide), but both had some drawbacks, such as low efficacy, instability, or side effects. Later, they discovered two substances, NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide), which are precursors of NAD+and can effectively increase NAD+levels. Among them, NMN is considered a superior choice because it is more easily absorbed and utilized by the human body than NR. In recent years, with the continuous deepening of research on NMN, NMN supplement has gradually become a popular anti-aging product, attracting the attention of many consumers and investors.

Firstly, NMN supplement is a molecular level anti-aging product that delays the cellular aging process by increasing NAD+levels in the human body. This is fundamentally different from other anti-aging products based on cell or organ levels. Secondly, NMN supplement is a systemic anti-aging product, which can improve many health problems related to aging, including brain health, heart health, diabetes and obesity, skin health and fertility. This has obvious advantages over other anti-aging products targeting specific problems or areas. Thirdly, NMN supplement is a natural and mild anti-aging product, which is a substance already present in the human body and does not cause allergies or adverse reactions. This is significantly different from other anti-aging products that contain chemical or pharmaceutical components.